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Some studies have shown that, if people with Down syndrome take the inactive oral forms of vitamin B12 and folate, their bodies may have difficulty converting from the inactive to the active form and the inactive form may not be as effective

By targeting the NNMT enzyme, it may help enhance cellular energy, promote fat utilization, and support lean muscle retention

The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again

Essential metabolic can be impaired as a result of decreased mitochondrial activity brought on by low NAD+ levels