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Some of the symptoms that MCAS can impact the body include: Constitutional- fatigue, fever, weight loss/gain Central nervous system- migraines/headaches, brain fog, panic attacks, anxiety, depression, insomnia Digestive system- GERD, dysphagia, chest pain, nausea, dyspepsia, bloating, abdominal pain, constipation, diarrhea Immune system- poor healing Salivary glands- swelling Skin flushing, hives, rashes, swelling, itching Pulmonary dyspnea, asthma, cough Extremities pain, swelling, vasospasm, numbness An Overview of MCAS MCAS or mast cell activation syndrome is an autoinflammatory disease that causes the mast cells in the body to be overstimulated due to allergens that have entered the body