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Professional liability considerations are important, as the use of non-FDA approved compounds may carry different legal risks compared to approved medications

Folate Deficiency Avoid use of sulfamethoxazole and trimethoprim in patients with impaired renal or hepatic function, in those with possible folate deficiency (e.g., the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states) and in those with severe allergies or bronchial asthma

Dec 2009;12(4):198-203

Those results do not prove equivalence or superiority for every product labelled liposomal