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Some guidelines recommend holding GLP-1 receptor agonists before procedures requiring sedation or general anesthesia to reduce the risk of aspiration, though specific recommendations may vary based on the procedure type and individual patient factors

Water: Helps transport nutrients to the liver Assists in the elimination of toxins through urine Supports blood circulation, which is crucial for liver function While individual needs vary, aiming for approximately 2-3 liters (8-10 cups) of water daily is a reasonable goal for most adults

A recent phase 2 trial investigated the triple biased GLP-1/GIP/GCC receptors agonist retatrutide (LY3437943) in 338 patients with a mean age of 48 years and BMI of 37.3 kg/m 2 without diabetes (prediabetes in 36% participants) showing BW and WC reduction ranging from 8.7% to 24.2% and 6.5 cm to 19.6 cm in the 1 mg and 12 mg dose groups, respectively, at 48 weeks 41