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For human SFB, these data show that multiple species within the SFB clade exist within the human population and validate our workflow and criteria used to bioinformatically identify SFB-positive samples in publicly available 16S rRNA gene amplicon sequence deposits

The binding site for the transcription factor, NF-B, on the cystathionine -lyase promoter is critical for LPS-induced cystathionine -lyase expression

NSAIDs and corticosteroids should be prescribed under professional supervision, with regular clinical evaluations to monitor adverse outcomes