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The addition of catalase suppressed cancer cell death and confirmed the important role of hydrogen peroxide in this anticancer mechanism of action involving ascorbate (Fig

The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

This enzyme is believed to be primarily located in the cytosol, with some presence in the mitochondrial intermembrane gap (Warris and Ballou, 2019)

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