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We hypothesized that disrupting endothelial IGF- 1R signaling would impair functional hyperemia, reduce microvascular density, and compromise skeletal muscle endurance, replicating aspects of the aging phenotype

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While subcutaneous injections are generally well tolerated, some patients experience mild to moderate localized reactions at the injection site

Regarding corticosterone levels, which directly indicate stress in murine models, a decrease was noted shortly after DSIP exposure