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There is good evidence, but not with absolute certainty, that the smoke with the more cancer-causing agents gets deeper to the lungs where adenocarcinomas more commonly occur. Efforts to contact major tobacco companies and industry groups for comment on this study were not successful

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Thus, we aimed to investigate how cigarette smoking affects body weight, food intake, plasma leptin concentration, hypothalamic NPY peptide, adipose mass and mRNA expression of uncoupling proteins (UCP), and tumor necrosis factor (TNF)

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