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A plethora of PASC clinical symptoms and related metabolic impairments indicate involvement of different pathobiological mechanisms such as (i) virus-induced hypoxia/Warburg effect, (ii) iron (Fe)-redox dysregulation (FeRD), (iii) m- Dys and altered bioenergetics, (iv) oxidative stress (OxS) and cellular damage, (v) immuno-pathogenesis and hyperinflammation, (vi) autoimmunity, (vii) dysbiosis, (viii) re-activation of latent pathogens, (ix) persistent viral reservoirs, and (x) viral-hijacked host cellular factors 22,27,137,138

A visit to a healthcare professional is the best course of action in cases like these.

Nrf2 is also upregulated by hyperbaric oxygen therapy in normal human endothelial cells (27) and in diseases (28, 29)

One is the immediacy of getting a diagnosis, points out Browd