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Research models suggest FOXO4-DRI may support: Vascular flexibility Endothelial health Reduced inflammatory signaling Improved circulatory function These areas continue to attract interest within cardiovascular aging research

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These designs have been useful in dissecting which weight-related endpoints depend on IGF-1 and which are truly GH-independent a question of ongoing interest in obesity and metabolic science

+ Preclinical work examines its role in cellular repair processes , metabolic efficiency, and stress-response signaling