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BoDBooks on Demand, 2012.

doi: 10.1016/j.biopha.2009.09.009

Abstract The global obesity epidemic and its associated metabolic disorders urgently require more effective therapeutic interventions, particularly multi-pathway targeting therapies

Throughout the 8 weeks of study, arginine depletion was found sustainable in all patients treated with pegylated arginase I, apparently the patients did not develop resistance to pegylated arginase I