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According to CDC, emphysema is seen in 15-20 percent of heavy smokers

Orofacial clefts, cleft lip and cleft palate affect feeding, speech and overall development

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Leveraging self-reported symptoms as listed under the World Health Organizations International Classifications of Diseases and Injuries (ICD) 10th Revision 5 or the American Psychiatric Associations Diagnostic and Statistical Manual Fifth Edition (DSM-5) 6 to diagnose nicotine dependence, researchers have traditionally relied on self-report measures to assess perceived dependence on TNPs