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PREVIEW Wells Fargo & Company Q1 2022 Earnings Conference Call April 14, 2022 Executives in Attendance: John Campbell - Director, IR Charlie Scharf - CEO Mike Santomassimo - CFO Analysts Present: Scott Siefers - Piper Sandler Steven Chubak - Wolfe Research John Pancari - Evercore ISI Ken Usdin - Jefferies John McDonald - Autonomous Research Ebrahim Poonawala - Bank of America Betsy Graseck - Morgan Stanley Matt OConnor - Deutsche Bank Erika Najarian - UBS Charles Peabody - Portales Partner Gerard Cassidy - RBC Capital Market Erika Najarian - UBS Comments from Charlie Scharf - CEO: Now, let me update you on progress weve made on our strategic priorities

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extreme caloric restriction may exacerbate menstrual irregularities Micronutrient optimization: Maintain adequate iron intake, particularly if experiencing heavier menstrual bleeding Contraceptive considerations: Discuss alternative contraceptive methods with your provider, as tirzepatide may affect oral contraceptive absorption For women with pre-existing menstrual irregularities or PCOS, tirzepatide treatment may ultimately improve cycle regularity as metabolic parameters normalize

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