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The LPS model is simpler, but different bacterial sources of LPS as well as the dosage of LPS and the way of administering LPS may affect the success of modeling and the severity of AKI

Another study developed pH/ROS dual-responsive metformin-released-enhanced self-healing bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic acid and L-arginine co-grafted chitosan hydrogel to enhance wound healing through decreased inflammation and enhanced angiogenesis in a rat type II diabetic model

J Biol Chem 280: 2649126498

Its effects on metabolic and appetite-signaling pathways continue to be an active area of cell-based research