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Production and purification of refolded recombinant Plasmodium falciparum beta-ketoacyl-ACP reductase from inclusion bodies

One important consideration is that only three published human clinical trials exist for BPC-157

In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]

Zhou H., Li X., Li Y., Zhu X., Zhang L., and Li J., Synthesis and Bioevaluation of 1Phenylimidazole4Carboxylic Acid Derivatives as Novel Xanthine Oxidoreductase Inhibitors, European Journal of Medicinal Chemistry 186 (2020): 111883, 10.1016/j.ejmech.2019.111883