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These initial studies reported increased NAD + and NAM levels in plasma, and in urine, the excreted NAD + levels increased after 6 h 66 , but it must be noted that these trials utilized small cohorts and short testing periods, and only a minor trend for cognitive improvement was observed 117

Key features Selected peptidic fraction from Saccharomyces cerevisiae Clinically proven benefits on a total of 135 subjects Reduction of caloric intake significant after the first weeks (down to -600kcal/day after 8 weeks) Significant weight loss after the first month Weight loss is from fat mass reduction Abdominal fat and waist circumference significantly decrease Water-soluble and heat-resistant

10.1016/j.theriogenology.2021.01.011 32

Early trials show promising changes in blood sugar, insulin resistance, inflammation, and liver fat