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Please note: Public comments to the board are due December 9

For instance, PGC1-related coactivators can activate the expression of NRF1, NRF2, and transcription factor A (TFAM, the final effectors of mtDNA transcription and replication) to regulate the expression of respiratory chain and the biogenesis of mitochondria, a process that has been well-documented in previous reviews (Scarpulla, 2008

Heart and Circulatory Physiology 281 (4): H1561-7

High levels of these acute phase reactants correlate directly with the severity of disease activity and are predictive of a higher risk for subsequent structural and radiographic joint damage (Shmerling & Greisen, 2025)