Moreover, riboflavin has been shown to directly stimulate the release of anti-inflammatory cytokines (e.g., IL-10, IL-12p70) and immune modulators (i.e., MCP-1, HMGB1, Hsp72, Hsp25) 49,50
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Furthermore, it also induces the expression of mitochondrial transcription factor A (TFAM), a controller in replication and transcription of mitochondrial DNA, to further drive mitochondrial biogenesis (Singh et al., 2018)