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Dihexa is orally bioavailable in animal models, with cognitive effects comparable to subcutaneous injection a property virtually absent among conventional neuropeptides that require intranasal or injectable delivery (PMID: 23055539)

Low SAM may limit methyl-donor reserve and could interfere with SAM-dependent creatine synthesis

Specifically, Lactobacillus murinus was the most upregulated genus under metformin treatment (Fig

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