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Orphanet J Rare Dis 16:308

Camerota L, Ritelli M, Wischmeijer A, Majore S, Cinquina V, Fortugno P, Monetta R, Gigante L, Marfan Syndrome Study Group Tor Vergata University Hospital, Sangiuolo FC, Novelli G, Colombi M, Brancati F

Note: This data comes from clinical trials

By contrast, the structurally-related antiandrogen bicalutamide, does not undergo amide hydrolysis in man 6 , with few cases of hepatotoxicity having been reported in the literature 7