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Immune resilience may improve, with some individuals noticing reduced frequency or duration of minor illnesses during glutathione therapy

While the greater amount of cellular reduced GSH is found in the cytosol and mitochondria, the endoplasmic reticulum becomes a reservoir of small concentrations of the oxidized form of GSH (GSSG)

Kim EH, Surh YJ (2008) The role of 15-deoxy-12,14-prostaglandin J2, an endogenous ligand of peroxisome proliferator-activated receptor , in tumor angiogenesis

Taken together, these findings suggest that APR-246 could induce tumor cell death through both reactivation of mutant p53 and inhibition of cellular thiol-dependent redox system proteins (GPX4, TXNDR1, GRX1), providing novel combinatorial strategies for AML therapy