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Mitochondrial dysfunction and oxidative damage in a part of the brain called the substantia nigra may play a role in the development of the disease (60)

At specific time intervals (12, 24, and 48 h), the bio-distribution of orid-liposome or TLR2 pep-orid-liposome in the organs and tumors was quantitatively evaluated by an in vivo optical imaging system ( n = 3)

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However, other molecules, including angiopoietins and metalloproteinases, also influence the crosstalk between endothelial cells and innate immune cells in the TME (4648, 74, 76, 77, 81, 109) ( Figure 3 )