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Description

This small molecule, dihexa, penetrates the BBB, induces spinogenesis/synaptogenesis at picomolar concentrations [70] , and is slowly cleared from the blood (plasma stability t 1/2 = 335.5 min) [73]

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[DOI] [PubMed] [Google Scholar] Jun JH, Lee SH, Kwak HB, Lee ZH, Seo SB, Woo KM, Ryoo HM, Kim GS, Baek JH

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Receptor Binding and Downstream Signaling IGF-1 LR3 binds IGF1R with affinity similar to native IGF-1, preserving the receptor-level pharmacology while altering the pharmacokinetics

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