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601 Future large, randomized studies with prespecified neurologic endpoints are warranted to determine the effects of SGLT2 inhibitors on DN

Cells were treated with ferroptosis inducers including erastin (SelleckChem) and RSL3 (Sigma Aldrich), ferroptosis inhibitor ferrostatin-1 (Sigma Aldrich), -glutamylcysteine synthetase inhibitor L-Buthionine-(S,R)-sulfoximine, (BSO, Sigma Aldrich) and IRE1 inhibitors 48c (Sigma Aldrich) and MKC9989 (MedChemExpress)