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Rafraf et al., 2012[39]

However, to test the concepts in vivo, and in particular, in the case of cancer, the mice should not only express human FcRn but also all the human forms of FcRs to fully address the therapeutic effect of enhanced half-life and biodistribution combined with tailored engagement of effector molecules and immune cells

We still do not know which group of patients is predisposed to adverse reactions after taking FQs