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Gluatatyon eksiklii i faktrlerden oluabilecei gibi ok fazla deterjan, aseton, metal, gdalarda bulunan yapay tatlandrclar ile d faktrler nedeniyle de oluabiliyor

Real-time PCR Total RNA, from either frozen liver tissues or cultured cells, was isolated by phenol-chloroform extraction

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Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)