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In a pooled post-hoc analysis of data obtained with liraglutide and semaglutide, a 53% lower risk was found of dementia compared with placebo

however, under specific circumstances, persistently activated mitophagy can temporarily decrease mitochondrial-derived ROS levels while releasing excessive levels of iron, which accelerates the Fenton reaction and impairs the normal function of related proteins, forming a vicious cycle that ultimately leads to irreversible iron-dependent cell death

Acknowledgements The authors thank Lovely Professional University for the continuous support and technical assistance during the review process

doi: 10.1016/j.ijpharm.2019.03.041 2 TatovicDMcAteerMABarryJBarrientosARodriguez TerradillosKPereraIet al