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The Phase IIb efficacy trials did not meet their efficacy endpoints, and clinical development for the original therapeutic indication was halted

As a more severe procedure, chronic unpredictable stress (after 5 d of unpredictable stress protocol, once daily drug application during stress procedure, open field-immobility test assessment at fourth or sixth day of medication) was used

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Furthermore, professional quality assurance protocols help preserve formulation integrity and stable analytical performance during scientific investigations