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Collectively, these findings represent the first biomarker/molecular difference that has been found to be different between children affected with konzo as compared to unaffected individuals and may serve as a biomarker for not only disease, but to identify children that harbor increased risk for disease susceptibility and severity
Moreover, the metal nanoprodrug NPS-G-Fe produced by coordinating Fe 3+ and gallic acid (GA) with Ce6 in photoactivated Pt(IV) containing nanoprodrug and then coating with PEG-modified chondroitin sulfate (PEG-CS) can lead to iron dissociation under acidic tumor microenvironment conditions, and NPS-G-Fe can promote macrophage polarization to M1 phenotype after radiotherapy thereby enhancing anti-tumor efficacy (35)
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