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Meta-analyses and clinical studies have associated the MTHFR 677TT genotype with increased ASD risk, possibly through mechanisms involving impaired methylation, elevated homocysteine, and altered neurodevelopmental signaling

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The end product of this reaction (AGE), in turn, induce oxidative stress and accelerate the Maillard reactions ultimately leading to inflammation and the propagation of tissue damage [30, 31, 32]