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However, the GSH/GSSG ratio is reduced in neurodegenerative diseases, such as Parkinsons disease (PD) and Alzheimers disease (AD)

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Although many of the contradictory results and conclusions reported over the years can be attributed to lack of understanding of established mechanisms, methodological problems, and misinterpretation of data, it is increasingly recognized that some of the reported differences in signaling mechanisms and even a switch in the mode of cell death can be caused by variations in the experimental conditions