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For example, people who have pernicious anemia, a condition in which they cannot make intrinsic factor which is needed for B12 absorption are not able to use vitamin B12 from foods or dietary supplements

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THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption

Key areas of research interest include the following