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The combination of declining estrogen, changing androgen ratios, and the metabolic stress of weight loss creates a perfect storm for follicular disruption

And Jayes adds: We didnt have the means to put them together. That changed in 2019, when they got their chance in the form of a pilot project grant from the Duke Clinical & Translational Science Institute designed specifically to facilitate Duke-NCCU collaboration

Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607]

In glutamatergic neurons, glutamine is primarily deaminated in mitochondria by glutaminase (GLS, GA, or glutamine aminohydrolase) to form glutamate, which enters synaptic vesicles to complete the glutamate-glutamine cycle