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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Wang Y, Wei Z, Pan K, Li J, Chen Q

E.ZhouS.DiazL

Although they primarily target joints, central nervous system, gastrointestinal tract, and multiple systemic organs, respectively, a common hallmark across these diseases is a significant disruption in the balance of T cell subsets, particularly a dynamic imbalance between Th17 cells and Treg cells ( Figure 2 )