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It's important to start with a lower dose and gradually increase as advised by

After 12 days, the mice were sacrificed, and the tumor tissues were collected

Additional information Supplementary Information accompanies the paper on British Journal of Cancer website ( Supplementary information Rights and permissions From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License

Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis