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Then, by changing the surface properties of the MAPHP-particle system through coating surfactants (e.g., T80), by overcoating with ApoE, B, A-I or by complexing with iron, the system could mimic the behavior of the apolipoprotein E- (ApoE) and apolipoprotein A-I (ApoA-I)-NPs, respectively, so as to cross the BBB and take the excess metals out of the brain with very limited toxicity (Davson and Segal, 1995

In the phase 1 study, 29 participants with SCD treated with mitapivat had a significant increase in mean hemoglobin of 1.2 g/dL, and 56.3% of participants achieved a 1-g/dL increase in hemoglobin from baseline

Neuroendocrinology , 113(4), 333-348