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Skin lightening was noticed in a patient as a side effect of large doses of glutathione, which was given for some other disease, and then onwards, it became more popular as a skin lightening agent

In each set, the time course is followed by the change from baseline (mean of days 3 to 1) to the mean of days 1-3, 7-9, and 18-20, as indicated

It is a comparatively recent discovery and a fast-growing subject of metabolic and longevity research