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These may include headaches, dizziness, and gastrointestinal issues like nausea or stomach pain

In a similar way, acrolein appears to stimulate oxidative stress damage, producing high levels of ceramide, which is accountable for the incrementation of cytosolic Ca 2+ concentration and, consequently, the eryptosis levels [254]

Peptide inhibitors (such as VY-9) occupy hydrophobic pockets (His85, Phe264, etc.) near the cavity entrance, which prevent the substrate L-tyrosine from entering the active cavity and interfere with the coordination between Cu and His residues (such as the chelation of imidazole ring of His85 with Cu), resulting in the loss of enzyme activity (Sepehri et al., 2022

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