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Step 3: The Therapies Then we add the therapies
Particularly in the last decade, several evidence have accumulated demonstrating increased prevalence of cardiovascular events, unfavourable metabolic changes and even mortality in AI patients with autonomous cortisol secretion (ACS) [2,3,4,5,6,7]
Factors that might warrant dose adjustment include body weight (with some research using weight-based dosing of 0.5-1.0 mcg/kg), response to first doses (with increases if effects are suboptimal or decreases if adverse effects occur), research phase (with possible dose increases in later phases of long-term protocols), and mix with other research compounds (which may need dose adjustments to account for combined effects)
Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signaling
