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The two main genes that produce the enzymes that break down histamine are DAO and HNMT ( 2)

Proinflammatory properties of glutathione peroxidase-4 Notably, the 718C allele of the GPX4 gene was found to be associated with the increased levels of lymphocyte lipoxygenase products implying that the polymorphism can modulate inflammatory processes through the regulation of the biosynthesis of leukotrienes, thromboxanes and prostaglandins

Glutathione tablets from reputable, FSSAI-approved brands are generally safe for healthy adults at standard doses (typically 250-500mg daily) for short to medium-term use