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Gritstone Biotech employed Venezuelan equine encephalitis virus-based self-amplifying mRNA vector in a lipid nanoparticle called GRT-R910 encoding both the prefusion stabilized full-length SARS-CoV-2 spike and additional conserved T-cell epitopes from ORF3a, NP and membrane (Table 3)

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By screening appropriately and choosing compounds based on both mechanism and medical history, we can maximize regenerative benefits while minimizing oncologic risk