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[32] This is to say, then, that the business of enhancing cognition in otherwise healthy subjects is rife with oft-unfulfilled promises and that claims of nootropic effect, especially those derived from findings in animal models of disease states or compromised cognition, should be approached with healthy skepticism

Key aspects in the design of such a model include the tumor cell source, which may be a cancer cell line, patient-derived primary or metastatic tissue, or three-dimensional co-culture systems (Fig

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