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Tirzepatide activates both GLP-1 and GIP receptors, resulting in slightly higher constipation rates (2527% in trials) compared to semaglutide (1520%)

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2.3 Univariable and multivariable regression analysis Adverse event data from eight ICIsnivolumab, pembrolizumab, cemiplimab, toripalimab, tislelizumab, atezolizumab, durvalumab, and avelumabwere pooled for regression analyses, with respiratory adverse events defined by PTs as the outcome of interest