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Animal studies

For instance, anti-CCP, a relatively specific biomarker, can be detected up to 10 years before the onset of RA symptoms, offering a valuable therapeutic window [150]

[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Chen S.H., Li C.W

In recent years, intranasal (IN) drug delivery has emerged as a promising strategy to bypass the BBB, providing a direct nose-to-brain delivery route via olfactory and trigeminal pathways while minimizing systemic exposure