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Additionally, the OI group may also have experienced variations in metabolites in response to the injury, whereas the majority of MRS in pediatric concussion literature has been conducted in comparison to a healthy population 14,15,16,17,34 , in which metabolite concentrations may be more homogeneous

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These processes result in the production of anticitrullinated protein antibodies (ACPAs) and rheumatoid factor prior to clinical symptom onset