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Seven of the 19 XChem hits were shown to bind to the protein, but with only a modest average peak intensity reduction of 2037% in the CPMG assay (Supplementary Table 2), suggesting that the fragments likely bound with weak (millimolar) affinities, at the very limit of the CPMG assay sensitivity

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It is important to remark that in humans, as in the rat [141], sex steroids would act mainly during the fetal and early neonatal stages, impregnating the hypothalamus so that from puberty there is an increase in the pulsatile secretion of GH, determined by an increase in the amplitude of the peaks rather than a change in secretory frequency [142]

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.De Rosa S.C., Zaretsky M.D., Dubs J.G., Roederer M., Anderson M., Green A., Mitra D., Watanabe N., Nakamura H., Tjioe I., et al