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From your mid-20s, natural collagen production declines by approximately 1% each year, gradually influencing elasticity, hydration and overall tissue integrity

Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, et al

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Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake