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Unlike GLP-1 agonists that primarily act on the hypothalamus, amylin agonists exert their strongest effects through brainstem area postrema activation and dramatic gastric slowing exceeding that of any other peptide class

MAPK is a key transmitter of signals from the cell surface to the nucleus and can be activated by factors such as cytokines, hormones, stressors and others to regulate cell growth, differentiation, inflammation and other physiological and pathological processes (92)