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Supplementing with Metabolic Regulators Acarbose, GlyNAC, and canagliflozin constitute promising metabolic modulators with evidence showing that they can also extend mouse lifespan

Published phase 3 trial data, including the OASIS 1 trial (Knop et al., 2023), show that high-dose oral semaglutide produced substantial body weight reduction at 68 weeks, with outcomes that approached those seen in injectable semaglutide trials, though these comparisons are not head-to-head