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J Lab Clin Med 1967

Exposure to microplastics leads to decreased mitochondrial function, induces oxidative stress and ferroptosis, and causes abnormal expression of genes related to mitochondrial function, such as increased expression of mitochondrial transcription factor A (TFAM), thereby associating them with neurodegenerative diseases including Alzheimers disease and Parkinsons disease (50)

1.3 Pentose Phosphate Pathway and NADPH Metabolism. In Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics

Yes, sun protection remains essential regardless of any skin treatment, as UV exposure is a major factor in pigmentation and skin dullness